According to the Pawnee creation myth, the wolf was the first creature to experience death. The Wolf Star, enraged at not having been invited to attend a council on how the Earth should be made, sent a wolf to steal the whirlwind bag of The Storm that Comes out of the West, which contained the first humans. Upon being freed from the bag, the humans killed the wolf, thus bringing death into the world.
The Pawnee, being both an agricultural and hunting people, associated the wolf with both corn and the bison; the “birth” and “death” of the Wolf Star (Sirius) was to them a reflection of the wolf’s coming and going down the path of the Milky Way known as Wolf Road.
[text from this Wikipedia article on Wolves in folklore, religion and mythology]